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mig [2018/11/18 11:36]
sflitman [Migraine]
mig [2019/07/21 22:39] (current)
sflitman [Migraine]
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 ^ Condition(s) ​ ^ Type of Drug  ^  Phase  ^  Add-On ​ ^  Placebo ​ ^  Duration ​ ^  Open-Label Extension ​ ^  ^ Condition(s) ​ ^ Type of Drug  ^  Phase  ^  Add-On ​ ^  Placebo ​ ^  Duration ​ ^  Open-Label Extension ​ ^
-| Treatment-resistant migraine prevention | Approved Emgality monthly injection |  III  |  Yes  |  50%  |  3 months ​ |  3 months ​ | 
 | Abortive therapy for acute migraine | Oral combination of two approved drugs |  III  |  Yes  |  33%  |  12 weeks  |  None  | | Abortive therapy for acute migraine | Oral combination of two approved drugs |  III  |  Yes  |  33%  |  12 weeks  |  None  |
  
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-| Episodic migraine abortive therapy ​ |  Novel non-triptan oral agent  |  III  |  Yes  |  50%  |  24 weeks  |+| Treatment-resistant migraine prevention | Approved Emgality monthly injection |  III  |  Yes  |  50%  |  3 months ​ |  3 months ​ || Episodic migraine abortive therapy ​ |  Novel non-triptan oral agent  |  III  |  Yes  |  50%  |  24 weeks  |
 | Episodic migraine, under 15 days per month |  Subcutaneous CGRP antagonist ​ |  III  |  No  |  50%  |  6 months of study agent, total duration 12 months ​ | | Episodic migraine, under 15 days per month |  Subcutaneous CGRP antagonist ​ |  III  |  No  |  50%  |  6 months of study agent, total duration 12 months ​ |
 | Chronic migraine, 15 or more days per month |  Subcutaneous CGRP antagonist ​ |  III  |  Yes, only Topamax or Inderal permitted ​ |  50% for 3 months, then 0% for 9 months ​ |  12 months of study agent, total duration 16 months. ​ |  ​ | Chronic migraine, 15 or more days per month |  Subcutaneous CGRP antagonist ​ |  III  |  Yes, only Topamax or Inderal permitted ​ |  50% for 3 months, then 0% for 9 months ​ |  12 months of study agent, total duration 16 months. ​ |  ​
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